diff --git a/.gitignore b/.gitignore
index a8bb1a6..910dc3b 100644
--- a/.gitignore
+++ b/.gitignore
@@ -1,2 +1,2 @@
-SOURCES/webkitgtk-2.50.0.tar.xz
+SOURCES/webkitgtk-2.50.1.tar.xz
 SOURCES/webkitgtk-keys.gpg
diff --git a/.webkit2gtk3.metadata b/.webkit2gtk3.metadata
index f7e19cf..51529c2 100644
--- a/.webkit2gtk3.metadata
+++ b/.webkit2gtk3.metadata
@@ -1,2 +1,2 @@
-1b4aba619d86d96a827d2accd109e5ad9b68dde8 SOURCES/webkitgtk-2.50.0.tar.xz
+b599be86497f57fc5b2eb8b5d60ff181fc651752 SOURCES/webkitgtk-2.50.1.tar.xz
 04b10b8a486542c4551269c20b18b5c1c6cb4f94 SOURCES/webkitgtk-keys.gpg
diff --git a/SOURCES/i686-build.patch b/SOURCES/i686-build.patch
deleted file mode 100644
index 13f98bc..0000000
--- a/SOURCES/i686-build.patch
+++ /dev/null
@@ -1,18 +0,0 @@
-diff --git a/Source/JavaScriptCore/llint/LowLevelInterpreter.asm b/Source/JavaScriptCore/llint/LowLevelInterpreter.asm
-index af53fe269664..237fd6aab9c8 100644
---- a/Source/JavaScriptCore/llint/LowLevelInterpreter.asm
-+++ b/Source/JavaScriptCore/llint/LowLevelInterpreter.asm
-@@ -2958,6 +2958,13 @@ _wasm_ipint_call_return_location_wide16:
- _wasm_ipint_call_return_location_wide32:
-     crash()
- 
-+if C_LOOP and not JSVALUE64
-+_op_instanceof_return_location:
-+_op_instanceof_return_location_wide16:
-+_op_instanceof_return_location_wide32:
-+    crash()
-+end
-+
- end # WEBASSEMBLY
- 
- include? LowLevelInterpreterAdditions
diff --git a/SOURCES/s390x-build.patch b/SOURCES/s390x-build.patch
deleted file mode 100644
index 7e1ea01..0000000
--- a/SOURCES/s390x-build.patch
+++ /dev/null
@@ -1,10 +0,0 @@
---- webkitgtk.orig/Source/WebCore/style/StyleBuilderState.cpp
-+++ webkitgtk/Source/WebCore/style/StyleBuilderState.cpp
-@@ -58,6 +58,7 @@
- #include "Settings.h"
- #include "StyleAppleColorFilterProperty.h"
- #include "StyleBuilder.h"
-+#include "StyleBuilderStateInlines.h"
- #include "StyleCachedImage.h"
- #include "StyleCanvasImage.h"
- #include "StyleColor.h"
diff --git a/SOURCES/webkitgtk-2.50.0.tar.xz.asc b/SOURCES/webkitgtk-2.50.0.tar.xz.asc
deleted file mode 100644
index 410fe44..0000000
--- a/SOURCES/webkitgtk-2.50.0.tar.xz.asc
+++ /dev/null
@@ -1,16 +0,0 @@
------BEGIN PGP SIGNATURE-----
-
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diff --git a/SOURCES/webkitgtk-2.50.1.tar.xz.asc b/SOURCES/webkitgtk-2.50.1.tar.xz.asc
new file mode 100644
index 0000000..4f3cbbe
--- /dev/null
+++ b/SOURCES/webkitgtk-2.50.1.tar.xz.asc
@@ -0,0 +1,16 @@
+-----BEGIN PGP SIGNATURE-----
+
+iQIzBAABCgAdFiEEAToBJ6ycZbNP+mJSbBAJtpOXU5MFAmjomvIACgkQbBAJtpOX
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+jPr8Y1RsbqObFzz36OscH/qT/KavXdwIUWX4WeA+gXe0z776NS8=
+=syt3
+-----END PGP SIGNATURE-----
diff --git a/SPECS/webkit2gtk3.spec b/SPECS/webkit2gtk3.spec
index e822a72..d115232 100644
--- a/SPECS/webkit2gtk3.spec
+++ b/SPECS/webkit2gtk3.spec
@@ -6,7 +6,7 @@
         cp -p %1 _license_files/$(echo '%1' | sed -e 's!/!.!g')
 
 Name:           webkit2gtk3
-Version:        2.50.0
+Version:        2.50.1
 Release:        1%{?dist}
 Summary:        GTK Web content engine library
 
@@ -46,11 +46,7 @@ Patch304:       icu60.patch
 ## Upstream patches to remove, hopefully after next update
 ##
 
-# https://bugs.webkit.org/show_bug.cgi?id=299018
-Patch400:       i686-build.patch
-
-# https://bugs.webkit.org/show_bug.cgi?id=298308
-Patch401:       s390x-build.patch
+# No patches currently! :)
 
 BuildRequires:  bison
 BuildRequires:  clang
@@ -317,6 +313,9 @@ export NINJA_STATUS="[%f/%t][%e] "
 %{_datadir}/gir-1.0/JavaScriptCore-4.0.gir
 
 %changelog
+* Mon Oct 13 2025 Michael Catanzaro <mcatanzaro@redhat.com> - 2.50.1-1
+- Update to 2.50.1
+
 * Tue Oct 07 2025 Michael Catanzaro <mcatanzaro@redhat.com> - 2.50.0-1
 - Update to 2.50.0