diff --git a/i686-build.patch b/i686-build.patch
deleted file mode 100644
index 13f98bc..0000000
--- a/i686-build.patch
+++ /dev/null
@@ -1,18 +0,0 @@
-diff --git a/Source/JavaScriptCore/llint/LowLevelInterpreter.asm b/Source/JavaScriptCore/llint/LowLevelInterpreter.asm
-index af53fe269664..237fd6aab9c8 100644
---- a/Source/JavaScriptCore/llint/LowLevelInterpreter.asm
-+++ b/Source/JavaScriptCore/llint/LowLevelInterpreter.asm
-@@ -2958,6 +2958,13 @@ _wasm_ipint_call_return_location_wide16:
- _wasm_ipint_call_return_location_wide32:
-     crash()
- 
-+if C_LOOP and not JSVALUE64
-+_op_instanceof_return_location:
-+_op_instanceof_return_location_wide16:
-+_op_instanceof_return_location_wide32:
-+    crash()
-+end
-+
- end # WEBASSEMBLY
- 
- include? LowLevelInterpreterAdditions
diff --git a/s390x-build.patch b/s390x-build.patch
deleted file mode 100644
index 7e1ea01..0000000
--- a/s390x-build.patch
+++ /dev/null
@@ -1,10 +0,0 @@
---- webkitgtk.orig/Source/WebCore/style/StyleBuilderState.cpp
-+++ webkitgtk/Source/WebCore/style/StyleBuilderState.cpp
-@@ -58,6 +58,7 @@
- #include "Settings.h"
- #include "StyleAppleColorFilterProperty.h"
- #include "StyleBuilder.h"
-+#include "StyleBuilderStateInlines.h"
- #include "StyleCachedImage.h"
- #include "StyleCanvasImage.h"
- #include "StyleColor.h"
diff --git a/sources b/sources
index 652580c..ff730c9 100644
--- a/sources
+++ b/sources
@@ -1,2 +1,2 @@
-SHA512 (webkitgtk-2.50.0.tar.xz) = 7e3a7ecdd71e21566b3e364ccb7573bec4f86c7cf5fbe5ce6f3fcbb1ed8e5674d9ed239b48fe330afe8f7370bbb323f6500f78a25f4572d8e02d7d274ec843b4
-SHA512 (webkitgtk-2.50.0.tar.xz.asc) = 68c62bd077f28816c0177e93fa01deae85619f55b510f204d57b59f6ae2d9c1bd1255c2dae4214e43ed2ef6c76f4cd42433f47af4146fcd1f14f707c7a377a80
+SHA512 (webkitgtk-2.50.1.tar.xz) = 4b7b6c5ae02f1dbcff26e7af4ee4e3cdd4435c61dfaf17c2981422358dea01cfba0ffe8c6f12c7864b6f1ee6c9906dfa64248bc95effed526e9ade3ad1292888
+SHA512 (webkitgtk-2.50.1.tar.xz.asc) = c430677ec8e147750f3dc69f2b6252da9bc9b4df61c0976213dea535be8973dc746b22137d508899d28095f58197e52ffa003ab2033b2c20a6c03d1a1b327e2c
diff --git a/webkit2gtk3.spec b/webkit2gtk3.spec
index e822a72..d115232 100644
--- a/webkit2gtk3.spec
+++ b/webkit2gtk3.spec
@@ -6,7 +6,7 @@
         cp -p %1 _license_files/$(echo '%1' | sed -e 's!/!.!g')
 
 Name:           webkit2gtk3
-Version:        2.50.0
+Version:        2.50.1
 Release:        1%{?dist}
 Summary:        GTK Web content engine library
 
@@ -46,11 +46,7 @@ Patch304:       icu60.patch
 ## Upstream patches to remove, hopefully after next update
 ##
 
-# https://bugs.webkit.org/show_bug.cgi?id=299018
-Patch400:       i686-build.patch
-
-# https://bugs.webkit.org/show_bug.cgi?id=298308
-Patch401:       s390x-build.patch
+# No patches currently! :)
 
 BuildRequires:  bison
 BuildRequires:  clang
@@ -317,6 +313,9 @@ export NINJA_STATUS="[%f/%t][%e] "
 %{_datadir}/gir-1.0/JavaScriptCore-4.0.gir
 
 %changelog
+* Mon Oct 13 2025 Michael Catanzaro <mcatanzaro@redhat.com> - 2.50.1-1
+- Update to 2.50.1
+
 * Tue Oct 07 2025 Michael Catanzaro <mcatanzaro@redhat.com> - 2.50.0-1
 - Update to 2.50.0