diff --git a/spice-gtk.spec b/spice-gtk.spec
index 07b8cde..caae04f 100644
--- a/spice-gtk.spec
+++ b/spice-gtk.spec
@@ -123,6 +123,9 @@ gpgv2 --quiet --keyring %{SOURCE2} %{SOURCE1} %{SOURCE0}
   %{mjpegflag} \
   %{celt051flag} \
   %{pulseflag} \
+%ifarch s390x # https://gitlab.freedesktop.org/spice/spice-gtk/issues/120
+  -Dusbredir=disabled \
+%endif
 %if 0%{?flatpak}
   -Dpolkit=disabled
 %else
@@ -194,6 +197,7 @@ gpgv2 --quiet --keyring %{SOURCE2} %{SOURCE1} %{SOURCE0}
 %changelog
 * Mon Mar 16 2020 Victor Toso <victortoso@redhat.com> - 0.38-1
 - Update to v0.38
+- s390x: disable usbredir
 
 * Tue Feb 25 2020 Marc-André Lureau <marcandre.lureau@redhat.com> - 0.37-6
 - Fix FTBFS https://bugzilla.redhat.com/show_bug.cgi?id=1800106