diff --git a/.gitignore b/.gitignore
index 3b40922..ab0e569 100644
--- a/.gitignore
+++ b/.gitignore
@@ -32,3 +32,4 @@ scipy-0.7.2.tar.gz
 /scipy-1.5.2.tar.gz
 /scipy-1.5.3.tar.gz
 /scipy-1.5.4.tar.gz
+/scipy-1.6.0.tar.gz
diff --git a/scipy.spec b/scipy.spec
index 3449da6..444aaad 100644
--- a/scipy.spec
+++ b/scipy.spec
@@ -14,8 +14,8 @@
 
 Summary:    Scientific Tools for Python
 Name:       scipy
-Version:    1.5.4
-Release:    2%{?dist}
+Version:    1.6.0
+Release:    1%{?dist}
 
 # BSD -- whole package except:
 # Boost -- scipy/special/cephes/scipy_iv.c
@@ -24,10 +24,8 @@ License:    BSD and Boost and Public Domain
 Url:        http://www.scipy.org/scipylib/index.html
 Source0:    https://github.com/scipy/scipy/releases/download/v%{version}/scipy-%{version}.tar.gz
 
-# https://github.com/scipy/scipy/pull/12899
-Patch0:     skip-certain-tests-on-32-bit-arches.patch
-# https://github.com/scipy/scipy/pull/13130
-Patch1:     skip-factorial-float-tests-on-py310.patch
+# https://github.com/scipy/scipy/pull/13387
+Patch0:     wavfile.patch
 
 BuildRequires: fftw-devel, suitesparse-devel
 BuildRequires: %{blaslib}-devel
@@ -173,6 +171,10 @@ popd
 %endif
 
 %changelog
+* Mon Jan 04 2021 Nikola Forró <nforro@redhat.com> - 1.6.0-1
+- New upstream release 1.6.0
+  resolves: #1906692
+
 * Wed Nov 25 2020 Nikola Forró <nforro@redhat.com> - 1.5.4-2
 - Skip factorial() float tests on Python 3.10
   resolves: #1898157
diff --git a/sources b/sources
index 6efb04d..3250601 100644
--- a/sources
+++ b/sources
@@ -1 +1 @@
-SHA512 (scipy-1.5.4.tar.gz) = d23f68911a8880f87767819750d4d175ba8f9c72fcb9b8080305ee65722c046d4485fde4f0c85cc53c46247dd99813afe675a38b3b0569a683ddc2c2e021b8fc
+SHA512 (scipy-1.6.0.tar.gz) = 995ffaf56b713cdd4bdb98d8525b892e9ad84a511878b43213cb71a67f34d87c111da36cf1e0b044c75c0d5af64bfde4ad0f3e9c5e71cae2dbf053251f37064e
diff --git a/wavfile.patch b/wavfile.patch
new file mode 100644
index 0000000..06258c5
--- /dev/null
+++ b/wavfile.patch
@@ -0,0 +1,36 @@
+commit 09d753f0ae71441906f5cee7a44b2d2b80212082
+Author: Nikola Forró <nforro@redhat.com>
+Date:   Thu Jan 14 14:34:14 2021 +0100
+
+    ENH: Support big-endian platforms and big-endian WAVs
+    
+    PR #12287 added support for reading arbitrary-bit-depth WAVs, but
+    the code doesn't consider big-endian WAVs, and doesn't work as expected
+    on big-endian platforms due to the use of native-byte-order data-types.
+    This change fixes that.
+    
+    There is also a simple test case that compares euqivalent RIFX
+    (big-endian) and RIFF (little-endian) files to verify the data read
+    are the same.
+
+diff --git a/scipy/io/wavfile.py b/scipy/io/wavfile.py
+index 9b5845d6b..951f8d201 100644
+--- a/scipy/io/wavfile.py
++++ b/scipy/io/wavfile.py
+@@ -458,10 +458,13 @@ def _read_data_chunk(fid, format_tag, channels, bit_depth, is_big_endian,
+ 
+         if dtype == 'V1':
+             # Rearrange raw bytes into smallest compatible numpy dtype
+-            dt = numpy.int32 if bytes_per_sample == 3 else numpy.int64
+-            a = numpy.zeros((len(data) // bytes_per_sample, dt().itemsize),
++            dt = f'{fmt}i4' if bytes_per_sample == 3 else f'{fmt}i8'
++            a = numpy.zeros((len(data) // bytes_per_sample, numpy.dtype(dt).itemsize),
+                             dtype='V1')
+-            a[:, -bytes_per_sample:] = data.reshape((-1, bytes_per_sample))
++            if is_big_endian:
++                a[:, :bytes_per_sample] = data.reshape((-1, bytes_per_sample))
++            else:
++                a[:, -bytes_per_sample:] = data.reshape((-1, bytes_per_sample))
+             data = a.view(dt).reshape(a.shape[:-1])
+     else:
+         if bytes_per_sample in {1, 2, 4, 8}: