diff --git a/kvm-e1000e-Prevent-crash-from-legacy-interrupt-firing-af.patch b/kvm-e1000e-Prevent-crash-from-legacy-interrupt-firing-af.patch
new file mode 100644
index 0000000..d1e4d00
--- /dev/null
+++ b/kvm-e1000e-Prevent-crash-from-legacy-interrupt-firing-af.patch
@@ -0,0 +1,69 @@
+From a2f30bafa346ef50932c359eaf71574ed3c1239d Mon Sep 17 00:00:00 2001
+From: Laurent Vivier <lvivier@redhat.com>
+Date: Thu, 7 Aug 2025 13:08:06 +0200
+Subject: [PATCH] e1000e: Prevent crash from legacy interrupt firing after
+ MSI-X enable
+MIME-Version: 1.0
+Content-Type: text/plain; charset=UTF-8
+Content-Transfer-Encoding: 8bit
+
+RH-Author: Laurent Vivier <lvivier@redhat.com>
+RH-MergeRequest: 403: e1000e: Prevent crash from legacy interrupt firing after MSI-X enable
+RH-Jira: RHEL-112882
+RH-Acked-by: Cindy Lu <lulu@redhat.com>
+RH-Acked-by: Jason Wang <jasowang@redhat.com>
+RH-Commit: [1/1] 8241a58b76307f27ad3d3b3b2106e00b153b7b53 (lvivier/qemu-kvm-centos)
+
+JIRA: https://issues.redhat.com/browse/RHEL-112882
+
+A race condition between guest driver actions and QEMU timers can lead
+to an assertion failure when the guest switches the e1000e from legacy
+interrupt mode to MSI-X. If a legacy interrupt delay timer (TIDV or
+RDTR) is active, but the guest enables MSI-X before the timer fires,
+the pending interrupt cause can trigger an assert in
+e1000e_intmgr_collect_delayed_causes().
+
+This patch removes the assertion and executes the code that clears the
+pending legacy causes. This change is safe and introduces no unintended
+behavioral side effects, as it only alters a state that previously led
+to termination.
+
+- when core->delayed_causes == 0 the function was already a no-op and
+  remains so.
+
+- when core->delayed_causes != 0 the function would previously
+  crash due to the assertion failure. The patch now defines a safe
+  outcome by clearing the cause and returning. Since behavior after
+  the assertion never existed, this simply corrects the crash.
+
+Resolves: https://gitlab.com/qemu-project/qemu/-/issues/1863
+Suggested-by: Akihiko Odaki <odaki@rsg.ci.i.u-tokyo.ac.jp>
+Signed-off-by: Laurent Vivier <lvivier@redhat.com>
+Acked-by: Jason Wang <jasowang@redhat.com>
+Reviewed-by: Akihiko Odaki <odaki@rsg.ci.i.u-tokyo.ac.jp>
+Message-ID: <20250807110806.409065-1-lvivier@redhat.com>
+Signed-off-by: Philippe Mathieu-Daudé <philmd@linaro.org>
+(cherry picked from commit 8e4649cac9bcddc050d2df07908075e9e69bccc7)
+---
+ hw/net/e1000e_core.c | 5 -----
+ 1 file changed, 5 deletions(-)
+
+diff --git a/hw/net/e1000e_core.c b/hw/net/e1000e_core.c
+index 2413858790..06657bb3ac 100644
+--- a/hw/net/e1000e_core.c
++++ b/hw/net/e1000e_core.c
+@@ -341,11 +341,6 @@ e1000e_intmgr_collect_delayed_causes(E1000ECore *core)
+ {
+     uint32_t res;
+ 
+-    if (msix_enabled(core->owner)) {
+-        assert(core->delayed_causes == 0);
+-        return 0;
+-    }
+-
+     res = core->delayed_causes;
+     core->delayed_causes = 0;
+ 
+-- 
+2.47.3
+
diff --git a/qemu-kvm.spec b/qemu-kvm.spec
index cfb4c7d..ae196e6 100644
--- a/qemu-kvm.spec
+++ b/qemu-kvm.spec
@@ -143,7 +143,7 @@ Obsoletes: %{name}-block-ssh <= %{epoch}:%{version}                    \
 Summary: QEMU is a machine emulator and virtualizer
 Name: qemu-kvm
 Version: 10.1.0
-Release: 1%{?rcrel}%{?dist}%{?cc_suffix}
+Release: 2%{?rcrel}%{?dist}%{?cc_suffix}
 # Epoch because we pushed a qemu-1.0 package. AIUI this can't ever be dropped
 # Epoch 15 used for RHEL 8
 # Epoch 17 used for RHEL 9 (due to release versioning offset in RHEL 8.5)
@@ -186,6 +186,8 @@ Patch0018: 0018-Add-support-statement-to-help-output.patch
 Patch0019: 0019-Use-qemu-kvm-in-documentation-instead-of-qemu-system.patch
 Patch0020: 0020-qcow2-Deprecation-warning-when-opening-v2-images-rw.patch
 Patch0021: 0021-file-posix-Define-DM_MPATH_PROBE_PATHS.patch
+# For RHEL-112882 - [DEV Task]: Assertion `core->delayed_causes == 0' failed with e1000e NIC
+Patch22: kvm-e1000e-Prevent-crash-from-legacy-interrupt-firing-af.patch
 
 %if %{have_clang}
 BuildRequires: clang
@@ -1265,6 +1267,11 @@ useradd -r -u 107 -g qemu -G kvm -d / -s /sbin/nologin \
 %endif
 
 %changelog
+* Mon Sep 15 2025 Miroslav Rezanina <mrezanin@redhat.com> - 10.1.0-2
+- kvm-e1000e-Prevent-crash-from-legacy-interrupt-firing-af.patch [RHEL-112882]
+- Resolves: RHEL-112882
+  ([DEV Task]: Assertion `core->delayed_causes == 0' failed with e1000e NIC)
+
 * Fri Aug 29 2025 Miroslav Rezanina <mrezanin@redhat.com> - 10.1.0-1
 - Rebase to QEMU 10.1.0 [RHEL-105035]
 - Resolves: RHEL-105035