diff --git a/python3.9.spec b/python3.9.spec
index 9c8729a..7d613c4 100644
--- a/python3.9.spec
+++ b/python3.9.spec
@@ -201,6 +201,12 @@ License: Python
 %{warn:Doing a main_python build with wrong %%__default_python3_pkgversion (0%{?__default_python3_pkgversion}, but this is %pyshortver)}
 %endif
 
+# Opt-out from https://fedoraproject.org/wiki/Changes/fno-omit-frame-pointer
+# Python is slower with frame pointers, but we expect to remove this in Python 3.12+
+# See https://lists.fedoraproject.org/archives/list/python-devel@lists.fedoraproject.org/thread/6TQYCHMX4FZLF27U5BCEC7IFV6XNBKJP/
+# Tracking bugzilla: https://bugzilla.redhat.com/2158729
+%undefine _include_frame_pointers
+
 # =======================
 # Build-time requirements
 # =======================