diff --git a/python-setuptools.spec b/python-setuptools.spec
index 01fe960..cf56988 100644
--- a/python-setuptools.spec
+++ b/python-setuptools.spec
@@ -28,7 +28,7 @@
 Name:           python-setuptools
 # When updating, update the bundled libraries versions bellow!
 Version:        53.0.0
-Release:        7%{?dist}
+Release:        8%{?dist}
 Summary:        Easily build and distribute Python packages
 # setuptools is MIT
 # appdirs is MIT
@@ -116,6 +116,11 @@ Summary:        The setuptools wheel
 Provides:       %{name}-wheel = %{version}-%{release}
 Obsoletes:      %{name}-wheel < %{version}-%{release}
 
+# Older versions of python3-libs expect Python wheels at the old unversioned
+# location, so we conflict with the old Python versions that wouldn't work with
+# the new wheel location.
+Conflicts:      python3-libs < 3.9.9-2
+
 %description -n %{python_wheel_pkg_prefix}-%{srcname}-wheel
 A Python wheel of setuptools to use with venv.
 %endif
@@ -207,6 +212,10 @@ PYTHONPATH=$(pwd) %pytest --ignore=pavement.py
 
 
 %changelog
+* Wed Nov 24 2021 Tomas Orsava <torsava@redhat.com> - 53.0.0-8
+- Conflict with old Python versions that use the old unversioned wheel location
+- Resolves: rhbz#1982668
+
 * Wed Sep 22 2021 Tomas Orsava <torsava@redhat.com> - 53.0.0-7
 - Make the python-setuptools-wheel subpackage versioned (python3-setuptools-wheel),
   and move its contents to a versioned directory /usr/share/python3-wheels