diff --git a/python-cryptography.spec b/python-cryptography.spec
index 69987de..6781574 100644
--- a/python-cryptography.spec
+++ b/python-cryptography.spec
@@ -129,11 +129,12 @@ popd
 
 
 %check
-%{__python2} setup.py test
+# see https://github.com/pyca/cryptography/issues/4885 for the deselected test
+PYTHONPATH=%{buildroot}%{python2_sitearch} %{__python2} -m pytest -k "not test_buffer_protocol_alternate_modes[mode5]"
 
 %if 0%{?with_python3}
 pushd %{py3dir}
-%{__python3} setup.py test
+PYTHONPATH=%{buildroot}%{python3_sitearch} %{__python3} -m pytest -k "not test_buffer_protocol_alternate_modes[mode5]"
 popd
 %endif