diff --git a/pyproject-rpm-macros.spec b/pyproject-rpm-macros.spec
index c3f65fd..a0cbcdb 100644
--- a/pyproject-rpm-macros.spec
+++ b/pyproject-rpm-macros.spec
@@ -6,7 +6,7 @@ License:        MIT
 
 # Keep the version at zero and increment only release
 Version:        0
-Release:        12%{?dist}
+Release:        13%{?dist}
 
 Source0:        macros.pyproject
 Source1:        pyproject_buildrequires.py
@@ -87,6 +87,9 @@ install -m 644 pyproject_buildrequires.py %{buildroot}%{_rpmconfigdir}/redhat/
 %license LICENSE
 
 %changelog
+* Mon Mar 02 2020 Miro Hrončok <mhroncok@redhat.com> - 0-13
+- Tox dependency generator: Handle deps read in from a text file (#1808601)
+
 * Wed Feb 05 2020 Miro Hrončok <mhroncok@redhat.com> - 0-12
 - Fallback to setuptools.build_meta:__legacy__ backend instead of setuptools.build_meta
 - Properly handle backends with colon
diff --git a/pyproject_buildrequires.py b/pyproject_buildrequires.py
index aa87481..9be8b36 100644
--- a/pyproject_buildrequires.py
+++ b/pyproject_buildrequires.py
@@ -189,6 +189,24 @@ def generate_run_requirements(backend, requirements):
         requirements.extend(requires, source=f'wheel metadata: {key}')
 
 
+def parse_tox_requires_lines(lines):
+    packages = []
+    for line in lines:
+        line = line.strip()
+        if line.startswith('-r'):
+            path = line[2:]
+            with open(path) as f:
+                packages.extend(parse_tox_requires_lines(f.read().splitlines()))
+        elif line.startswith('-'):
+            print_err(
+                f'WARNING: Skipping dependency line: {line}\n'
+                + f'    tox deps options other than -r are not supported (yet).',
+            )
+        else:
+            packages.append(line)
+    return packages
+
+
 def generate_tox_requirements(toxenv, requirements):
     requirements.add('tox-current-env >= 0.0.2', source='tox itself')
     requirements.check(source='tox itself')
@@ -203,7 +221,10 @@ def generate_tox_requirements(toxenv, requirements):
         if r.stdout:
             print_err(r.stdout, end='')
         r.check_returncode()
-        requirements.extend(depfile.read().splitlines(),
+
+        deplines = depfile.read().splitlines()
+        packages = parse_tox_requires_lines(deplines)
+        requirements.extend(packages,
                             source=f'tox --print-deps-only: {toxenv}')
 
 
diff --git a/tests/python-openqa_client.spec b/tests/python-openqa_client.spec
new file mode 100644
index 0000000..b6e7cc2
--- /dev/null
+++ b/tests/python-openqa_client.spec
@@ -0,0 +1,48 @@
+%global pypi_name openqa_client
+Name:           python-%{pypi_name}
+Version:        4.0.0
+Release:        1%{?dist}
+Summary:        Python client library for openQA API
+
+License:        GPLv2+
+URL:            https://github.com/os-autoinst/openQA-python-client
+Source0:        %{pypi_source}
+
+BuildArch:      noarch
+BuildRequires:  pyproject-rpm-macros
+
+%description
+This package uses tox.ini file with recursive deps (via the -r option).
+
+%package -n python3-%{pypi_name}
+Summary:        %{summary}
+%{?python_provide:%python_provide python3-%{pypi_name}}
+
+%description -n python3-%{pypi_name}
+%{summary}.
+
+
+%prep
+%autosetup -p1 -n %{pypi_name}-%{version}
+# setuptools-git is needed to build the source distribution, but not
+# for packaging, which *starts* from the source distribution
+sed -i -e 's., "setuptools-git"..g' pyproject.toml
+
+%generate_buildrequires
+%pyproject_buildrequires -t
+
+%build
+%pyproject_wheel
+
+%install
+%pyproject_install
+
+%check
+%tox
+
+
+%files -n python3-%{pypi_name}
+%doc README.*
+%license COPYING
+%{python3_sitelib}/%{pypi_name}/
+%{python3_sitelib}/%{pypi_name}-%{version}.dist-info/
diff --git a/tests/tests.yml b/tests/tests.yml
index 1ea7549..ac51c24 100644
--- a/tests/tests.yml
+++ b/tests/tests.yml
@@ -28,6 +28,9 @@
     - tldr:
         dir: .
         run: ./mocktest.sh tldr
+    - openqa_client:
+        dir: .
+        run: ./mocktest.sh python-openqa_client
     required_packages:
     - mock
     - rpmdevtools