diff --git a/6cb584e9de6e8d54f5576c299a308f89bfdcb519.patch b/6cb584e9de6e8d54f5576c299a308f89bfdcb519.patch
deleted file mode 100644
index 3192279..0000000
--- a/6cb584e9de6e8d54f5576c299a308f89bfdcb519.patch
+++ /dev/null
@@ -1,81 +0,0 @@
-From 6cb584e9de6e8d54f5576c299a308f89bfdcb519 Mon Sep 17 00:00:00 2001
-From: Sergei Izmailov <sergei.a.izmailov@gmail.com>
-Date: Tue, 8 Oct 2019 19:25:09 +0300
-Subject: [PATCH] Adapt to python3.8 C API change (#1950)
-
-* Adapt to python3.8 C API change
-
-Do `Py_DECREF(type)` on all python objects on deallocation
-
-fix #1946
-
-* Add bare python3.8 build to CI matrix
-
-While numpy/scipy wheels are available, run python3.8 test without them
----
- .travis.yml                     | 27 +++++++++++++++++++++++++++
- include/pybind11/detail/class.h |  6 ++++++
- 2 files changed, 33 insertions(+)
-
-diff --git a/.travis.yml b/.travis.yml
-index 381148e04..28f35f995 100644
---- a/.travis.yml
-+++ b/.travis.yml
-@@ -106,6 +106,33 @@ matrix:
-           - lld-7
-           - libc++-7-dev
-           - libc++abi-7-dev  # Why is this necessary???
-+  - os: linux
-+    dist: xenial
-+    env: PYTHON=3.8 CPP=17 GCC=7
-+    name: Python 3.8, c++17, gcc 7 (w/o numpy/scipy) # TODO: update build name when the numpy/scipy wheels become available
-+    addons:
-+      apt:
-+        sources:
-+          - deadsnakes
-+          - ubuntu-toolchain-r-test
-+        packages:
-+          - g++-7
-+          - python3.8-dev
-+          - python3.8-venv
-+    # Currently there is no numpy/scipy wheels available for python3.8
-+    # TODO: remove next before_install, install and script clause when the wheels become available
-+    before_install:
-+      - pyenv global $(pyenv whence 2to3)  # activate all python versions
-+      - PY_CMD=python3
-+      - $PY_CMD -m pip install --user --upgrade pip wheel setuptools
-+    install:
-+      - $PY_CMD -m pip install --user --upgrade pytest
-+    script:
-+      - |
-+        # Barebones build
-+        cmake -DCMAKE_BUILD_TYPE=Debug -DPYBIND11_WERROR=ON -DDOWNLOAD_CATCH=ON -DPYTHON_EXECUTABLE=$(which $PY_CMD) .
-+        make pytest -j 2
-+        make cpptest -j 2
-   - os: osx
-     name: Python 2.7, c++14, AppleClang 7.3, CMake test
-     osx_image: xcode7.3
-diff --git a/include/pybind11/detail/class.h b/include/pybind11/detail/class.h
-index ffdfefe74..230ae81ae 100644
---- a/include/pybind11/detail/class.h
-+++ b/include/pybind11/detail/class.h
-@@ -350,6 +350,7 @@ extern "C" inline void pybind11_object_dealloc(PyObject *self) {
-     auto type = Py_TYPE(self);
-     type->tp_free(self);
- 
-+#if PY_VERSION_HEX < 0x03080000
-     // `type->tp_dealloc != pybind11_object_dealloc` means that we're being called
-     // as part of a derived type's dealloc, in which case we're not allowed to decref
-     // the type here. For cross-module compatibility, we shouldn't compare directly
-@@ -357,6 +358,11 @@ extern "C" inline void pybind11_object_dealloc(PyObject *self) {
-     auto pybind11_object_type = (PyTypeObject *) get_internals().instance_base;
-     if (type->tp_dealloc == pybind11_object_type->tp_dealloc)
-         Py_DECREF(type);
-+#else
-+    // This was not needed before Python 3.8 (Python issue 35810)
-+    // https://github.com/pybind/pybind11/issues/1946
-+    Py_DECREF(type);
-+#endif
- }
- 
- /** Create the type which can be used as a common base for all classes.  This is
diff --git a/pybind11.spec b/pybind11.spec
index 8959ad1..8b26c59 100644
--- a/pybind11.spec
+++ b/pybind11.spec
@@ -14,8 +14,8 @@
 
 
 Name:    pybind11
-Version: 2.4.2
-Release: 2%{?dist}
+Version: 2.4.3
+Release: 1%{?dist}
 Summary: Seamless operability between C++11 and Python
 License: BSD
 URL:	 https://github.com/pybind/pybind11
@@ -23,8 +23,6 @@ Source0: https://github.com/pybind/pybind11/archive/v%{version}/%{name}-%{versio
 
 # Don't use pip to get path to headers
 Patch1:  pybind11-2.4.0-nopip.patch
-# Patch for Python 3.8 compatibility
-Patch2:  https://github.com/pybind/pybind11/commit/6cb584e9de6e8d54f5576c299a308f89bfdcb519.patch
 
 %if %{python2_enabled}
 # Needed to build the python libraries
@@ -103,7 +101,6 @@ This package contains the Python 3 files.
 %prep
 %setup -q
 %patch1 -p1 -b .nopip
-%patch2 -p1 -b .python38
 
 %build
 pys=""
@@ -171,6 +168,9 @@ PYBIND11_USE_CMAKE=true %py3_install "--install-purelib" "%{python3_sitearch}"
 %endif
 
 %changelog
+* Tue Oct 15 2019 Susi Lehtola - 2.4.3-1
+- Update to 2.4.3.
+
 * Tue Oct 08 2019 Susi Lehtola - 2.4.2-2
 - Fix Python 3.8 incompatibility.