diff --git a/243.patch b/243.patch
new file mode 100644
index 0000000..13791fc
--- /dev/null
+++ b/243.patch
@@ -0,0 +1,45 @@
+From 89e0c07e4aa991af307b113afa474fcdfffe0859 Mon Sep 17 00:00:00 2001
+From: Christoph Reiter <reiter.christoph@gmail.com>
+Date: Tue, 6 Oct 2020 14:21:33 +0200
+Subject: [PATCH] Don't assume Py_TYPE being a macro
+
+It got changed to a function in Python 3.10. Use the Py_SET_TYPE macro
+suggested at https://docs.python.org/3.10/whatsnew/3.10.html instead.
+
+Fixes #358
+---
+ giscanner/giscannermodule.c | 10 +++++-----
+ 1 file changed, 5 insertions(+), 5 deletions(-)
+
+diff --git a/giscanner/giscannermodule.c b/giscanner/giscannermodule.c
+index 43f8bdea2..46bfd105e 100644
+--- a/giscanner/giscannermodule.c
++++ b/giscanner/giscannermodule.c
+@@ -27,10 +27,6 @@
+ 
+ #include <glib-object.h>
+ 
+-#ifndef Py_TYPE
+-    #define Py_TYPE(ob) (((PyObject*)(ob))->ob_type)
+-#endif
+-
+ #if PY_MAJOR_VERSION >= 3
+     #define MOD_INIT(name) PyMODINIT_FUNC PyInit_##name(void)
+     #define MOD_ERROR_RETURN NULL
+@@ -52,8 +48,12 @@ PyTypeObject Py##cname##_Type = {             \
+     0                                         \
+ }
+ 
++#if PY_VERSION_HEX < 0x030900A4
++#  define Py_SET_TYPE(obj, type) ((Py_TYPE(obj) = (type)), (void)0)
++#endif
++
+ #define REGISTER_TYPE(d, name, type)	      \
+-    Py_TYPE(&type) = &PyType_Type;             \
++    Py_SET_TYPE(&type, &PyType_Type);         \
+     type.tp_alloc = PyType_GenericAlloc;      \
+     type.tp_new = PyType_GenericNew;          \
+     type.tp_flags = Py_TPFLAGS_DEFAULT | Py_TPFLAGS_BASETYPE; \
+-- 
+GitLab
+
diff --git a/gobject-introspection.spec b/gobject-introspection.spec
index 8ad1618..8e46295 100644
--- a/gobject-introspection.spec
+++ b/gobject-introspection.spec
@@ -4,13 +4,16 @@
 
 Name:           gobject-introspection
 Version:        1.66.1
-Release:        1%{?dist}
+Release:        2%{?dist}
 Summary:        Introspection system for GObject-based libraries
 
 License:        GPLv2+, LGPLv2+, MIT
 URL:            https://wiki.gnome.org/Projects/GObjectIntrospection
 Source0:        https://download.gnome.org/sources/gobject-introspection/1.66/%{name}-%{version}.tar.xz
 
+# Fix the build with Python 3.10
+Patch0:         243.patch
+
 BuildRequires:  gcc
 BuildRequires:  bison
 BuildRequires:  cairo-gobject-devel
@@ -86,6 +89,9 @@ Libraries and headers for gobject-introspection
 %{_mandir}/man1/g-ir-scanner.1*
 
 %changelog
+* Wed Nov 04 2020 Kalev Lember <klember@redhat.com> - 1.66.1-2
+- Backport an upstream MR to fix the build with Python 3.10 (#1893194)
+
 * Mon Oct  5 2020 Kalev Lember <klember@redhat.com> - 1.66.1-1
 - Update to 1.66.1