diff --git a/boost-1.73-python3.10-Py_fopen.patch b/boost-1.73-python3.10-Py_fopen.patch
new file mode 100644
index 0000000..047403f
--- /dev/null
+++ b/boost-1.73-python3.10-Py_fopen.patch
@@ -0,0 +1,29 @@
+From ba90b0adffb5fedc894889b0962c22fff5bb748d Mon Sep 17 00:00:00 2001
+From: Tomas Hrnciar <thrnciar@redhat.com>
+Date: Thu, 7 Jan 2021 11:46:29 +0100
+Subject: [PATCH] fix Boost with Python 3.10
+
+---
+ src/exec.cpp | 4 ++--
+ 1 file changed, 2 insertions(+), 2 deletions(-)
+
+diff --git a/src/exec.cpp b/src/exec.cpp
+index 171c6f41..caa7d086 100644
+--- a/libs/python/src/exec.cpp
++++ b/libs/python/src/exec.cpp
+@@ -106,10 +106,10 @@ object BOOST_PYTHON_DECL exec_file(char const *filename, object global, object l
+   char *f = const_cast<char *>(filename);
+   // Let python open the file to avoid potential binary incompatibilities.
+ #if PY_VERSION_HEX >= 0x03040000
+-  FILE *fs = _Py_fopen(f, "r");
++  FILE *fs = fopen(f, "r");
+ #elif PY_VERSION_HEX >= 0x03000000
+   PyObject *fo = Py_BuildValue("s", f);
+-  FILE *fs = _Py_fopen(fo, "r");
++  FILE *fs = fopen(fo, "r");
+   Py_DECREF(fo);
+ #else
+   PyObject *pyfile = PyFile_FromString(f, const_cast<char*>("r"));
+-- 
+2.29.2
+
diff --git a/boost.spec b/boost.spec
index b2b9740..c0ffd30 100644
--- a/boost.spec
+++ b/boost.spec
@@ -42,7 +42,7 @@ Name: boost
 %global real_name boost
 Summary: The free peer-reviewed portable C++ source libraries
 Version: 1.73.0
-Release: 11%{?dist}
+Release: 12%{?dist}
 License: Boost and MIT and Python
 
 # Replace each . with _ in %%{version}
@@ -175,6 +175,9 @@ Patch93: boost-1.73-python3.10.patch
 # https://github.com/boostorg/locale/issues/52
 Patch94: boost-1.73-locale-empty-vector.patch
 
+# https://bugzilla.redhat.com/show_bug.cgi?id=1912903
+Patch95: boost-1.73-python3.10-Py_fopen.patch
+
 %bcond_with tests
 %bcond_with docs_generated
 
@@ -693,6 +696,7 @@ find ./boost -name '*.hpp' -perm /111 | xargs chmod a-x
 %patch92 -p1
 %patch93 -p1
 %patch94 -p1
+%patch95 -p1
 
 %build
 %set_build_flags
@@ -1304,6 +1308,9 @@ fi
 %{_mandir}/man1/b2.1*
 
 %changelog
+* Fri Jan  8 14:14:00 CET 2021 Tomas Hrnciar <thrnciar@redhat.com> - 1.73.0-12
+- Patch Boost.Python for Python 3.10 - replace _Py_fopen() with fopen() (#1912903)
+
 * Fri Nov 20 2020 Jonathan Wakely <jwakely@redhat.com> - 1.73.0-11
 - Patch Boost.Locale to not access empty vector (#1899888)