diff --git a/6003.patch b/6003.patch
new file mode 100644
index 0000000..9f3222b
--- /dev/null
+++ b/6003.patch
@@ -0,0 +1,50 @@
+From 829611469a979f499f3658fba632c9d9fe96933e Mon Sep 17 00:00:00 2001
+From: Victor Stinner <vstinner@python.org>
+Date: Fri, 16 Feb 2024 09:02:35 +0100
+Subject: [PATCH] Use Python 3.13a4 PyCFunctionFastWithKeywords
+
+Python 3.13a4 adds a public PyCFunctionFastWithKeywords and
+PyCFunctionFast types and removes the private
+_PyCFunctionFastWithKeywords and _PyCFunctionFast types:
+
+* https://github.com/python/cpython/commit/9e3729bbd77fb9dcaea6a06ac760160136d80b79
+* https://github.com/python/cpython/pull/114627
+* https://github.com/capi-workgroup/decisions/issues/11
+---
+ Cython/Utility/CythonFunction.c  | 2 +-
+ Cython/Utility/ModuleSetupCode.c | 9 +++++++--
+ 2 files changed, 8 insertions(+), 3 deletions(-)
+
+diff --git a/Cython/Utility/CythonFunction.c b/Cython/Utility/CythonFunction.c
+index 2a3b67335d2..646e3f5ff3a 100644
+--- a/Cython/Utility/CythonFunction.c
++++ b/Cython/Utility/CythonFunction.c
+@@ -1019,7 +1019,7 @@ static PyObject * __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS(PyObject *func,
+         return NULL;
+     }
+ 
+-    return ((_PyCFunctionFastWithKeywords)(void(*)(void))def->ml_meth)(self, args, nargs, kwnames);
++    return ((__Pyx_PyCFunctionFastWithKeywords)(void(*)(void))def->ml_meth)(self, args, nargs, kwnames);
+ }
+ 
+ static PyObject * __Pyx_CyFunction_Vectorcall_FASTCALL_KEYWORDS_METHOD(PyObject *func, PyObject *const *args, size_t nargsf, PyObject *kwnames)
+diff --git a/Cython/Utility/ModuleSetupCode.c b/Cython/Utility/ModuleSetupCode.c
+index 785fcc653ef..03373b50f13 100644
+--- a/Cython/Utility/ModuleSetupCode.c
++++ b/Cython/Utility/ModuleSetupCode.c
+@@ -907,8 +907,13 @@ class __Pyx_FakeReference {
+   typedef PyObject *(*__Pyx_PyCFunctionFastWithKeywords) (PyObject *self, PyObject *const *args,
+                                                           Py_ssize_t nargs, PyObject *kwnames);
+ #else
+-  #define __Pyx_PyCFunctionFast _PyCFunctionFast
+-  #define __Pyx_PyCFunctionFastWithKeywords _PyCFunctionFastWithKeywords
++  #if PY_VERSION_HEX >= 0x030d00A4
++  #  define __Pyx_PyCFunctionFast PyCFunctionFast
++  #  define __Pyx_PyCFunctionFastWithKeywords PyCFunctionFastWithKeywords
++  #else
++  #  define __Pyx_PyCFunctionFast _PyCFunctionFast
++  #  define __Pyx_PyCFunctionFastWithKeywords _PyCFunctionFastWithKeywords
++  #endif
+ #endif
+ 
+ #if CYTHON_METH_FASTCALL
diff --git a/Cython.spec b/Cython.spec
index e1cd0f8..5ffd014 100644
--- a/Cython.spec
+++ b/Cython.spec
@@ -13,6 +13,9 @@ License:        Apache-2.0
 URL:            http://www.cython.org
 Source:         https://github.com/cython/cython/archive/%{version}/Cython-%{version}.tar.gz
 
+# Use Python 3.13.0a4 PyCFunctionFastWithKeywords
+Patch:          https://github.com/cython/cython/pull/6003.patch
+
 BuildRequires:  python3-devel
 
 %if %{with tests}